Tanshinone IIA Reverses the Malignant Phenotype of SGC7901 Gastric Cancer Cells
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چکیده
منابع مشابه
Study on optimisation of extraction process of tanshinone IIA and its mechanism of induction of gastric cancer SGC7901 cell apoptosis.
The objective of this paper was to investigate the extraction process of tanshinone IIA and its mechanism of induction of gastric cancer SGC7901 cell apoptosis. Extraction process of tanshinone IIA was optimised by orthogonal experimental method, and its effect on gastric cancer SGC7901 cell apoptosis was observed using MTT assay and electron microscopy. The optimum extraction process of tanshi...
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Tanshinone IIA (TSN) exhibits a variety of anticancer effects. However, whether it inhibits gastric cancer (GC) cell proliferation and migration and the mechanism remain unclear. In the present study, different concentrations of TSN were co-incubated with SGC-7901 cells. The pcDNA-FOXM1 or FOXM1-siRNA plasmid was transfected into cells before treatment with 5 µg/l TSN. The proliferation and mig...
متن کاملInhibitory Effect of Tanshinone IIA on Rat Hepatic Stellate Cells
BACKGROUND Anti-inflammation via inhibition of NF-κB pathways in hepatic stellate cells (HSCs) is one therapeutic approach to hepatic fibrosis. Tanshinone IIA (C19H18O3, Tan IIA) is a lipophilic diterpene isolated from Salvia miltiorrhiza Bunge, with reported anti-inflammatory activity. We tested whether Tan IIA could inhibit HSC activation. MATERIALS AND METHODS The cell line of rat hepatic ...
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ژورنال
عنوان ژورنال: Asian Pacific Journal of Cancer Prevention
سال: 2013
ISSN: 1513-7368
DOI: 10.7314/apjcp.2013.14.1.173